Coronaviral ion channels as target for Chinese herbal medicine
ABSTRACT A variety of viruses encode for proteins that can form ion channels in the
membrane of infected cells. For example, the protein coded by the open-reading-frame 3a of …
membrane of infected cells. For example, the protein coded by the open-reading-frame 3a of …
[HTML][HTML] Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus
The protein coded by the open-reading-frame 3a of SARS coronavirus has been
demonstrated to form a cation-selective channel that may become expressed in the infected …
demonstrated to form a cation-selective channel that may become expressed in the infected …
Emodin inhibits current through SARS-associated coronavirus 3a protein
S Schwarz, K Wang, W Yu, B Sun, W Schwarz - Antiviral research, 2011 - Elsevier
The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated
previously to form a cation-selective channel that may become expressed in the infected cell …
previously to form a cation-selective channel that may become expressed in the infected cell …
[HTML][HTML] Structure and inhibition of the SARS coronavirus envelope protein ion channel
K Pervushin, E Tan, K Parthasarathy, X Lin… - PLoS …, 2009 - journals.plos.org
The envelope (E) protein from coronaviruses is a small polypeptide that contains at least
one α-helical transmembrane domain. Absence, or inactivation, of E protein results in …
one α-helical transmembrane domain. Absence, or inactivation, of E protein results in …
[HTML][HTML] SARS coronavirus E protein forms cation-selective ion channels
L Wilson, C Mckinlay, P Gage, G Ewart - Virology, 2004 - Elsevier
Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV).
Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic …
Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic …
The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function
The severe acute respiratory syndrome-coronavirus (SARS-CoV) caused an outbreak of
atypical pneumonia in 2003. The SARS-CoV viral genome encodes several proteins which …
atypical pneumonia in 2003. The SARS-CoV viral genome encodes several proteins which …
Pentameric viral ion channels: from structure to function
A family of small polypeptides in many virus types associate to form oligomers and have
channel activity. These proteins have been referred to as viroporins or virochannels and are …
channel activity. These proteins have been referred to as viroporins or virochannels and are …
Molecular and genetic characterisation of the SARS coronavirus auxiliary protein X1 in Drosophila.
1. We have generated monoclonal antibodies against the SARS coronavirus (SARS-CoV)
X1/3a protein (3a), which are suitable for western blotting, immunocytochemistry, and …
X1/3a protein (3a), which are suitable for western blotting, immunocytochemistry, and …
Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release
W Lu, BJ Zheng, K Xu, W Schwarz… - Proceedings of the …, 2006 - National Acad Sciences
Fourteen ORFs have been identified in the severe acute respiratory syndrome-associated
coronavirus (SARS-CoV) genome. ORF 3a of SARS-CoV codes for a recently identified …
coronavirus (SARS-CoV) genome. ORF 3a of SARS-CoV codes for a recently identified …
The SARS Coronavirus 3a protein binds calcium in its cytoplasmic domain
Abstract The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a positive
stranded RNA virus with∼ 30 kb genome. Among all open reading frames (orfs) of this virus …
stranded RNA virus with∼ 30 kb genome. Among all open reading frames (orfs) of this virus …