Growing evidence underscores nociceptor-immune system interactions in regulating chronic
pain and inflammatory diseases. Opioid receptors play a role in modulating pain-associated …

Mitragyna speciosa is a tropical plant with narcotic effects. The antinociceptive effects of its
crude extracts, bioactive compounds and structurally modified derivatives have been …

Mitragyna speciosa Korth is a medicinal plant indigenous to Thailand and Malaysia and has
been known for its narcotic and coca-like effects. Many studies have been performed on the …

Cannabinoids and opioids systems share numerous pharmacological properties and
antinociception is one of them. Previous findings have shown that mitragynine (MG), a major …

The use of natural products as traditional medicines, remedies, potions and oils have been
described since ancient times for the treatment of many diseases. Plant derived natural …

Objectives: To screen the analgesic effect of aqueous and alcoholic extract of Madhuka
longifolia and elucidate its probable mechanism of action. Method: The analgesic effect was …

Mitragynine is an indole alkaloid isolated from the Thai medicinal plant Mitragyna speciosa.
We previously reported the morphine-like action of mitragynine and its related compounds in …

Pain is associated with many health problems and a reduced quality of life and has been a
common reason for seeking medical attention. Several therapeutics are available on the …

The leaves of Mitragyna speciosa Korth.(M. speciosa) were extracted with methanol to give
methanol extract. The methanol extract was made in acid and then in alkaline and extracted …

Context: Menthol, the main monoterpene found in Mentha piperita L.(M. piperita) is known to
modulate nociceptive threshold and is present in different curative preparations that reduce …