Amiodarone is effective in suppressing arrhythmias in heart failure patients. We investigated
the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular …

We examined the effect of high-(AHD) and low-dose (ALD) amiodarone on survival,
hemodynamics, and left ventricular remodeling in rats with experimental myocardial …

Background—It is unclear how amiodarone therapy exerts its effects on left ventricular
remodeling and cardiac sympathetic nerve function in chronic heart failure. We investigated …

Aims This study investigated whether chronic and acute amiodarone treatment has
differential effects on ventricular arrhythmogenesis during acute myocardial infarction in rats …

Background: Pharmacokinetics and tissue concentrations of amiodarone may vary
considerably in end-stage heart failure, but may be crucial for treatment efficiency and …

Amiodarone is a potent antiarrhythmic agent with complex chronic effects, notably on
repolarization and conduction, that are not fully understood. Its low arrhythmogenic potential …

Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial
infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was …

Background Although trials of amiodarone therapy in patients with congestive heart failure
have produced discordant results with regard to effects on survival, most studies have …

Bicer, S., Patchell, JS, Hamlin, DM, Hamlin, RL Acute effects of escalating doses of
amiodarone in isolated guinea pig hearts. J. vet Pharmacol. Therap. 25, 221–226. Cardiac …

Background: Acute and chronic treatment with amiodarone has been reported to cause
different electrocardiographic changes in patients. The cellular electrophysiologic effects of …