Cellular life is orchestrated by the biochemical components of cells that include nucleic
acids, lipids, carbohydrates, proteins, and cofactors such as metabolites and metals, all of …

Artificial metalloenzymes combine the inherent reactivity of transition metal catalysis with the
sophisticated reaction control of natural enzymes. By providing new opportunities in …

Residing at the interface of chemistry and biotechnology, artificial metalloenzymes (ArMs)
offer an attractive technology to combine the versatile reaction repertoire of transition metal …

Expanding the repertoire of reactions available to enzymes is an enduring challenge in
biocatalysis. Owing to the synthetic versatility of transition metals, metalloenzymes have …

Combining organometallics and biology has generated broad interest from scientists
working on applications from in situ drug release to biocatalysis. Engineered enzymes and …

Bioinorganic chemists have become engaged in the challenge of elucidating the molecular
mechanisms that govern how protein scaffolds modulate the properties of metal cofactors …

In recent years, substantial advances have been made in the development of artificial
metalloenzymes. These hybrid bioinorganic catalysts have seen their selectivity improved …

Highlights•Artificial metalloenzymes result from incorporation of a metal cofactor in a
protein.•These biohybrids catalyze abiotic transformations.•Artificial metalloenzymes can be …

A large fraction of metalloenzymes harbors multiple metal-centers that are electronically
and/or functionally arranged within their proteinaceous environments. To explore the …

Conspectus Natural metalloenzymes are often the most proficient catalysts in terms of their
activity, selectivity, and ability to operate at mild conditions. However, metalloenzymes are …