Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

Colorectal cancer is the second most common cancer diagnosed in men and the third most
commonly occurring in women worldwide. Interactions between cells and the surrounding …

The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

Collagens are the main components of extracellular matrix in the tumor microenvironment.
Both fibrillar and nonfibrillar collagens are involved in tumor progression. The nonfibrillar …

Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They
mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer …

Interactions with the extracellular matrix (ECM) provide cells with physical and chemical
cues that act in concert with growth factors to support survival and proliferation …

Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities
and the matrix itself in dynamic, bidirectional processes. One such process is local …

Progression through dissemination to tumor-surrounding tissues and metastasis
development is a hallmark of cancer that requires continuous cell-to-cell interactions and …

Integrin-mediated adhesion of cells to the extracellular matrix (ECM) is crucial for the
physiological development and functioning of tissues but is pathologically disrupted in …

Cell transformation and tumor progression involve a common set of acquired capabilities,
including increased proliferation, failure of cell death, self-sufficiency in growth …