Epithelial dysfunction in chronic respiratory diseases, a sh... : Current Opinion in Pulmonary
Medicine Epithelial dysfunction in chronic respiratory diseases, a shared endotype? : Current …

The airway epithelium is now considered to be central to the orchestration of pulmonary
inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first …

The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

The rising trends in asthma over the past 30 years are likely to be a consequence of
changes in the environment acting on a susceptible genotype. Recognising that …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

In spite of substantial advances in defining the immunobiology and function of structural
cells in lung diseases there is still insufficient knowledge to develop fundamentally new …

The lung develops from a very simple outpouching of the foregut into a highly complex,
finely structured organ with multiple specialized cell types that are required for its normal …

Epithelial cells lining the airways and the respiratory compartment may, and certainly when
exposed to an inflammatory milieu, display an altered functioning, which could contribute to …

The airway epithelium comprises of different cell types and acts as a physical barrier
preventing pathogens, including inhaled particles and microbes, from entering the lungs …

Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …