UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
CB Jones, MK Clements… - … journal of oncology, 2000 - spandidos-publications.com
Previous research has shown synergistic growth inhibition between UCN-01 and
camptothecin (CPT) in tumor cells with mutant p53 versus tumor cells with wild-type p53. To …
camptothecin (CPT) in tumor cells with mutant p53 versus tumor cells with wild-type p53. To …
Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G2 arrest
CB Jones, MK Clements, S Wasi, SS Daoud - Cancer chemotherapy and …, 2000 - Springer
Purpose: To determine the ability of UCN-01 to abrogate the cell cycle arrest induced by
camptothecin (CPT) in tumor cells that lack p53 function, and therefore enhance the …
camptothecin (CPT) in tumor cells that lack p53 function, and therefore enhance the …
Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
A Redkar, P Mixter, SS Daoud - Journal of experimental …, 2004 - search.ebscohost.com
Abstract We previously reported (Cancer Chemother Pharmacol 45: 252-258, 2000) that
UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, which is under clinical trials as …
UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, which is under clinical trials as …
Role of wild-type p53 in the enhancement of camptothecin cytotoxicity against human prostate tumor cells.
IN Arah, K Song, P Seth, KH Cowan… - Anticancer research, 1998 - europepmc.org
The role of wild-type human p53 protein in enhancing camptothecin cytotoxicity was
examined by infecting human prostate PC3 cells with adenovirus expressing human wild …
examined by infecting human prostate PC3 cells with adenovirus expressing human wild …
Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
M Gupta, S Fan, Q Zhan, KW Kohn, PM O'Connor… - Clinical cancer research …, 1997 - AACR
Camptothecin (CPT) derivatives are topoisomerase I (top1) inhibitors recently introduced as
clinical agents. To explore the role of p53 in CPT-induced cytotoxicity, we examined CPT …
clinical agents. To explore the role of p53 in CPT-induced cytotoxicity, we examined CPT …
Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin.
A Deptala, X Li, E Bedner… - International …, 1999 - spandidos-publications.com
Abstract The DNA topoisomerase I (topI) inhibitor camptothecin (CPT), stabilizes so-called
cleavable complexes which consist of topI covalently attached to 3'OH ends of DNA nicks …
cleavable complexes which consist of topI covalently attached to 3'OH ends of DNA nicks …
An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells
IMM van Leeuwen, B Rao, MCC Sachweh, S Laín - Cell cycle, 2012 - Taylor & Francis
Pharmacological activation of wild-type p53 has been found to protect normal cells in culture
from cytotoxicity and nuclear aberrations caused by conventional cancer therapeutics …
from cytotoxicity and nuclear aberrations caused by conventional cancer therapeutics …
UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines
A Monks, ED Harris, A Vaigro-Wolff, CD Hose… - Investigational New …, 2000 - Springer
UCN-01 is undergoing Phase I evaluation and is a candidate forcombination strategies in
the clinic. UCN-01 has been shown to havea variety of effects on cellular targets and the cell …
the clinic. UCN-01 has been shown to havea variety of effects on cellular targets and the cell …
Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.
S Fan, B Cherney, W Reinhold, K Rucker… - Clinical cancer research …, 1998 - AACR
In the present study, we report our findings on the impact of p53 disruption on the sensitivity
of human cell lines to the antimitotic agents Taxol and vincristine. Comparisons of cell …
of human cell lines to the antimitotic agents Taxol and vincristine. Comparisons of cell …
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly …
RG Shao, CX Cao, T Shimizu, PM O'Connor, KW Kohn… - Cancer research, 1997 - AACR
Hydroxystaurosporine (UCN-01) is a selective protein kinase C inhibitor in clinical trial for
cancer treatment. In this study, we found that nanomolar concentrations of camptothecin …
cancer treatment. In this study, we found that nanomolar concentrations of camptothecin …