[HTML][HTML] Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of …
B Chen, Y Feng, M Zhang, G Cheng… - American Journal of …, 2019 - ncbi.nlm.nih.gov
The direct interaction between Cullin 4B (CUL4B) and DNA damage-binding protein 1
(DDB1) is required for the assembly of Cullin4B-RING E3 ligase complex (CRL4B), which …
(DDB1) is required for the assembly of Cullin4B-RING E3 ligase complex (CRL4B), which …
[HTML][HTML] Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4DCAF4 E3 ligases to inhibit colorectal cancer cell growth
C Yang, J Wu, H He, H Liu - International Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Abstract Cullin 4A and 4B (CUL4A and 4B) function as oncogenes in colorectal cancer
(CRC) cells. Both of them conservatively associate with DNA damage-binding protein 1 …
(CRC) cells. Both of them conservatively associate with DNA damage-binding protein 1 …
Activation of TNF‐α/NF‐κB axis enhances CRL4BDCAF11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
C Zhang, B Chen, K Jiang, L Lao, H Shen… - Molecular …, 2018 - Wiley Online Library
Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3
ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma …
ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma …
[HTML][HTML] CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells
Z Chen, BL Shen, QG Fu, F Wang… - Oncology …, 2014 - spandidos-publications.com
Abstract Cullin 4B (CUL4B) is a component of the Cullin4B-Ring E3 ligase complex
(CRL4B) that functions in proteolysis and is implicated in tumorigenesis. Here, we report that …
(CRL4B) that functions in proteolysis and is implicated in tumorigenesis. Here, we report that …
[HTML][HTML] CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells
Z Chen, K Wang, C Hou, K Jiang, B Chen, J Chen… - Scientific reports, 2017 - nature.com
Cell cycle progression in mammals is strictly controlled by a number of cyclin-dependent
kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in …
kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in …
[HTML][HTML] The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications
Y Sang, F Yan, X Ren - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract CRLs (Cullin-RING E3 ubiquitin ligases) are the largest E3 ligase family in
eukaryotes, which ubiquitinate a wide range of substrates involved in cell cycle regulation …
eukaryotes, which ubiquitinate a wide range of substrates involved in cell cycle regulation …
[PDF][PDF] Decreased CUL4B expression inhibits malignant proliferation of glioma in vitro and in vivo
J Dong, XQ Wang, JJ Yao, G Li… - Eur Rev Med Pharmacol …, 2015 - europeanreview.org
OBJECTIVE: Cullin 4B (CUL4B) is a component of the Cullin 4B-Ring E3 ligase complex
(CRL4B) that plays a role in proteolysis and is implicated in tumorigenesis. However, little is …
(CRL4B) that plays a role in proteolysis and is implicated in tumorigenesis. However, little is …
[HTML][HTML] Pathogenic role of the CRL4 ubiquitin ligase in human disease
J Lee, P Zhou - Frontiers in oncology, 2012 - frontiersin.org
The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1–CUL4 associated
factors substrate receptors to direct the degradation of proteins involved in a wide spectrum …
factors substrate receptors to direct the degradation of proteins involved in a wide spectrum …
[HTML][HTML] Knockdown of CUL4B suppresses the proliferation and invasion in non-small cell lung cancer cells
X Wang, Z Chen - Oncology Research, 2016 - ncbi.nlm.nih.gov
Abstract Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase
complexes, was found to be overexpressed in many types of tumors. However, the …
complexes, was found to be overexpressed in many types of tumors. However, the …
DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression
BQ Shan, XM Wang, L Zheng, Y Han, J Gao… - Cancer …, 2022 - Wiley Online Library
Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently
discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 …
discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 …