More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

More than a third of all bacterial polypeptides, comprising the 'exportome', are transported to
extracytoplasmic locations. Most of the exportome is targeted and inserts into …

The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Significant strides have been made during the past 20 years in our understanding of protein
secretion across the bacterial inner membrane. Specialized chaperones select secretory …

Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …

Bacteria and archaea possess a protein complex in the plasma membrane that governs
protein secretion and membrane protein insertion. Eukaryotes carry homologues in the …

About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

All living organisms, no matter how simple or complex, possess the ability to translocate
proteins across biological membranes and into different cellular compartments. Although a …

Like the conductor of an orchestra, the Sec protein translocation channel is the platform
needed to bring together the many different players required for the constitutive and …