Background: Homozygous or compound heterozygous mutations in high temperature
requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal …

Background and Objectives Cerebral autosomal recessive arteriopathy with subcortical
infarcts and leukoencephalopathy (CARASIL) is a rare hereditary cerebrovascular disease …

High temperature requirement serine peptidase A1 (HTRA1) related cerebral small vessel
disease (CSVD) includes both symptomatic heterozygous HTRA1 variant carrier and …

Background Biallelic HTRA1 pathogenic variants are associated with autosomal recessive
cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Recent …

Cerebral autosomal recessive arteriopathy with subcortical infarcts and
leukoencephalopathy (CARASIL) is clinically characterized by early-onset dementia, stroke …

Cerebral autosomal recessive arteriopathy with subcortical infarcts and
leukoencephalopathy (CARASIL) is a hereditary cerebral small vessel disease (CSVD) …

Heterozygous HTRA1 mutations, recently, have been reported as a cause of autosomal
dominant hereditary cerebral small vessel disease (CSVD). We herein describe clinical and …

Cerebral small vessel disease represents a heterogeneous group of disorders leading to
stroke and cognitive impairment. While most small vessel diseases appear sporadic and …

Objective To describe and compare two cases of North American and African patients who
were diagnosed with HTRA1-related cerebral small vessel disease (CSVD) with …

Background and Purpose—Homozygous and compound heterozygous mutations in the
high temperature requirement serine peptidase A1 gene (HTRA1) cause cerebral autosomal …