Abstract Background: In 1889, Stephen Paget hypothesized that metastatic cells‐the “seeds”‐
only grow in the secondary sites‐the soil”‐with a permissive microenvironment. Here, we …

Abstract Background: In 1889, Stephen Paget hypothesized that metastatic cells-the “seeds”-
only grow in the secondary sites-the “soil”-with a permissive microenvironment. Here, we …

Metastatic cancer cells only grow in the secondary sites with a permissive
microenvironment. Here, we show that the metastatic cells can also carry their own “soil” …

Metastatic cancer cells (seeds) preferentially grow in the secondary sites with a permissive
microenvironment (soil). We show that the metastatic cells can bring their own soil—stromal …

Metastatic dissemination is the leading cause of cancer death. Each year in the United
States more than 500,000 people die principally as a result of the metastatic spread of …

The role of stromal cells in the tumor microenvironment has been extensively characterized.
We and others have shown that stromal cells may participate in several steps of the …

The stroma in human carcinomas consists of extracellular matrix and various types of non-
carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone …

It seems evident that truly major strides in preventing cancer deaths will come only from the
universal application of strategies, which can limit the initial occurrence of neoplasia or …

Cancer tissues are composed of cancer cells and the surrounding stromal cells (eg,
fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular …

Stromal cells have been studied extensively in the primary tumor microenvironment. In
addition, mesenchymal stromal cells may participate in several steps of the metastatic …