Calcium-sensing receptor and associated diseases

GN Hendy, V Guarnieri, L Canaff - Progress in molecular biology and …, 2009 - Elsevier
The calcium-sensing receptor (CASR) is expressed in parathyroid hormone (PTH)-secreting
cells of the parathyroid gland and cells lining the renal tubule. The activated CASR …

Calcium-sensing receptor: Role in health and disease

RV Thakker - Indian Journal of Endocrinology and Metabolism, 2012 - journals.lww.com
The calcium-sensing receptor (CaSR) is a 1,078 amino acid G protein-coupled receptor
(GPCR), which is predominantly expressed in the parathyroids and kidney. The CaSR …

Diseases associated with the extracellular calcium-sensing receptor

RV Thakker - Cell calcium, 2004 - Elsevier
The human calcium-sensing receptor (CaSR) is a 1078 amino acid cell surface protein,
which is predominantly expressed in the parathyroids and kidney, and is a member of the …

Mutations of the calcium‐sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant …

GN Hendy, L D'Souza‐Li, B Yang, L Canaff… - Human …, 2000 - Wiley Online Library
The calcium‐sensing receptor (CASR) is a plasma membrane G protein coupled receptor
that is expressed in the parathyroid hormone (PTH) producing chief cells of the parathyroid …

[HTML][HTML] Disorders of the calcium-sensing receptor

RV Thakker - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 1998 - Elsevier
The human calcium-sensing receptor (CaSR) is a 1078-amino-acid cell surface protein
which is expressed in the parathyroids, thyroid cells and the kidney, and is a member of the …

Diseases associated with calcium-sensing receptor

C Vahe, K Benomar, S Espiard, L Coppin… - Orphanet journal of rare …, 2017 - Springer
The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by
regulating parathyroid hormone secretion and urinary calcium excretion. The diseases …

Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism

FM Hannan, RV Thakker - Best practice & research Clinical endocrinology …, 2013 - Elsevier
The extracellular calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor
(GPCR) that is expressed at multiple sites, including the parathyroids and kidneys. The …

Clinical and laboratory features of calcium-sensing receptor disorders: a systematic review

IR Gunn, D Gaffney - Annals of clinical biochemistry, 2004 - journals.sagepub.com
Mutations in the calcium-sensing receptor gene (CaSR) may result in disorders of calcium
homeostasis manifesting as familial benign hypocalciuric hypercalcaemia (FBHH), neonatal …

The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases

FM Hannan, E Kallay, W Chang, ML Brandi… - Nature Reviews …, 2019 - nature.com
Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …

[PDF][PDF] Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis

FM Hannan, VN Babinsky… - Journal of molecular …, 2016 - jme.bioscientifica.com
The extracellular calcium (Ca2+ o)-sensing receptor (CaSR) is a family CG protein-coupled
receptor, which detects alterations in Ca2+ o concentrations and modulates parathyroid …