Tumor‐infiltrating stroma cells (TISC) as well as tumors themselves are thought to be
involved in tumor‐related immunosuppression, which is one of the critical mechanisms of …

The potential of mesenchymal stromal cells (MSCs) to inhibit anti-tumor immunity is
becoming increasingly well recognized, but the precise steps affected by these cells during …

Therapeutic uses of mesenchymal stromal cells (MSCs) have emerged over the past
decade. Yet, their effect on tumor growth remains highly debated, particularly in an immune …

The growth of solid tumors depends on tumor stroma. A single adoptive transfer of CD8+
CTLs that recognize tumor antigen–loaded stromal cells, but not the cancer cells because of …

Background Tumour growth and metastatic infiltration are favoured by several components
of the tumour microenvironment. Bone marrow-derived multipotent mesenchymal stromal …

Solid tumors may modulate their environment and keep stromal cells in an
immunosuppressive and tumor-promoting state. Recent findings indicate that targeting not …

The tumor microenvironment (TME) plays a critical role in tumorigenesis and is comprised of
different components, including tumor cells, stromal cells, and immune cells. Among them …

Marrow stromal cells (MSCs) can be easily gene-modified and clonally expanded making
them ideal candidates for transgenic cell therapy. However, recent reports suggest that …

Tumor microenvironment represents the site where the tumor tries to survive and escape
from immune system-mediated recognition. Indeed, to proliferate tumor cells can divert the …

A dynamic and mutualistic interaction between tumour cells and the surrounding stroma
promotes the initiation, progression, metastasis and chemoresistance of solid tumours. Far …