1. Regional distribution of the serotonin transport complex was studied in 12 different brain
areas from human brains. The serotonin uptake complex was measured with 3 H …

The serotonin (5-HT) transporter from human striatum was solubilized by digitonin and
purified by affinity chromatography. The native protein-detergent complex had a molecular …

Previous studies have demonstrated that [3H] paroxetine and [3H] cyanoimipramine ([3H]
CN-IMI) are highly selective ligands for the serotonin (5-HT) transporter. Using membrane …

Abstract [125I] RTI‐55 was used in tracer doses to label serotonin (5‐HT) transporters in vivo
in the mouse brain. Fluoxetine, paroxetine, and sertraline, potent antidepressants and …

Binding of two different antidepressant drugs,[3H] paroxetine and [3H] imipramine in 30 rat
brain regions was visualized, corn-pared and quantified by means of autoradiography and …

Abstract [3H]-Imipramine and [3H]-paroxetine label with high affinity a site which is
associated with the serotonergic transporter in brain and platelets. The pharmacological …

The effects of 5‐hydroxytryptamine (5‐HT) and 5‐HT uptake inhibitors on the dissociation of
[3H] paroxetine from rat brain membrane binding sites have been investigated. The …

The binding of [3H] paroxetine and [3H] citalopram to the human brain serotonin (5-HT)
uptake site has been characterized and compared. Our results reveal that the binding …

Antidepressant agents with properties to inhibit 5-hydroxytryptamine (5-HT, serotonin)
uptake in brain tissue and platelets bind with high affinities to neuronal and platelet …

Paroxetine is the most potent and one of the most specific serotonin uptake inhibitors. High-
affinity 3 H-paroxetine and 3 H-imipramine binding was compared in rat neuronal …