Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

J Riegger, RE Brenner - International journal of molecular sciences, 2020 - mdpi.com
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …

[HTML][HTML] Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention

WC Kramer, KJ Hendricks, J Wang - International journal of clinical …, 2011 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is characterized by joint pain and stiffness with radiographic evidence of
joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA …

Post-traumatic osteoarthritis: a review of pathogenic mechanisms and novel targets for mitigation

JE Dilley, MA Bello, N Roman, T McKinley, U Sankar - Bone Reports, 2023 - Elsevier
Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …

Key pathways to prevent posttraumatic arthritis for future molecule-based therapy

S Chubinskaya, MA Wimmer - Cartilage, 2013 - journals.sagepub.com
Joint injuries are common, especially among young adults aged 18 to 44 years. They are
accompanied by a cascade of events that increase the risk of posttraumatic osteoarthritis …

Osteoarthritis: trauma vs disease

G Jiménez, J Cobo-Molinos, C Antich… - … , Current Strategies, and …, 2018 - Springer
Osteoarthritis (OA) is the most prevalent joint disease characterized by pain and
degenerative lesions of the cartilage, subchondral bone, and other joint tissues. The causes …

Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis

M Varela-Eirin, J Loureiro, E Fonseca… - Ageing research …, 2018 - Elsevier
Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

Insights on molecular mechanisms of chondrocytes death in osteoarthritis

E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Chondrocyte death involvement in osteoarthritis

S Salucci, E Falcieri, M Battistelli - Cell and tissue research, 2022 - Springer
Chondrocyte apoptosis is known to contribute to articular cartilage damage in osteoarthritis
and is correlated to a number of cartilage disorders. Micromass cultures represent a …

Post-traumatic osteoarthritis in mice following mechanical injury to the synovial joint

MF Rai, X Duan, JD Quirk, N Holguin, EJ Schmidt… - Scientific reports, 2017 - nature.com
We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA)
across the knee joint in response to mechanical injury. We hypothesized that alteration in …

Osteoarthritis and cartilage regeneration: Focus on pathophysiology and molecular mechanisms

S Grässel, A Aszodi - International Journal of Molecular Sciences, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of disability and source of societal cost in older adults.
It is a whole-joint disease in which all components of the joint are affected involving …