Background and purpose: Effects of imatinib mesylate, a Kit receptor tyrosine kinase
inhibitor, on spontaneous activity of interstitial cells of Cajal (ICC) and smooth muscles in the …

Abstract Interstitial cells of Cajal (ICCs) are postulated to serve as pacemakers that
physiologically generate electrical slow waves in the gastrointestinal tract. Imatinib is a novel …

The interstitial cells of Cajal (ICC) in the digestive tract and ICC-like cells in extradigestive
organs express the c-kit tyrosine-kinase receptor, and have been implicated as pacemakers …

MATERIALS AND METHODS Preparation of Cells and Cell Cultures The mice used were
treated ethically according to the Guidelines for the Care and Use of Animals approved by …

Aims In the gastrointestinal tract, slow wave activity in smooth muscle is generated by the
interstitial cells of Cajal (ICC). Detrusor smooth muscle strips of most species show …

Background: C-kit receptor expressing interstitial cells generate and coordinate the electrical
signals that control peristalsis in the gut. However, the function of interstitial cells in the …

Although it is well known that the reduction of interstitial cells of Cajal (ICCs) is associated
with several gastrointestinal motility disorders in clinic, it is unknown whether the mature …

Discussion This report describes a high plasma concentration of imatinib caused by intake
of an overdose along with two minor tranquillizers, brotizolam and triazolam. The loss of …

Electrical slow waves, generated by interstitial cells of Cajal (ICC), cause spontaneous
contractions of human stomach. Software was developed to measure muscle tone and …

What's known on the subject? and What does the study add? Several studies have
examined the functional role of tyrosine kinase receptors in the generation of spontaneous …