Background and objective Severe asthma is responsible for a disproportionate burden of
illness and healthcare costs spent on asthma. This study analyses sputum transcriptomics to …

Background and objective Severe asthma (SA) is a heterogeneous disease. Transcriptomic
analysis contributes to the understanding of pathogenesis necessary for developing new …

Background Airway inflammation is associated with asthma exacerbation risk, treatment
response, and disease mechanisms. Objective This study aimed to identify and validate a …

Background Severe asthma is a complex disease. Transcriptomic profiling has contributed
to understanding the pathogenesis of asthma, especially type‐2 inflammation. However …

Background Sputum analysis in asthmatic patients is used to define airway inflammatory
processes and might guide therapy. Objective We sought to determine differential gene and …

Systemic inflammation is reported to be associated with neutrophilic airway inflammation in
asthma, but mechanisms underlying this finding are not well understood. This study aimed to …

Background It is now recognized that asthma can present in different forms. Typically,
asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of …

Background: Type 2 (T2) inflammation drives airway dysfunction in many patients with
asthma; yet, we lack a comprehensive understanding of the airway immune cell types and …

Asthma is a chronic inflammatory disorder associated with airway hyper-responsiveness.
Although a number of studies have investigated asthma at the molecular level, the molecular …

Background Asthma is a chronic airway inflammatory disease; however, the molecular
mechanisms that underlie asthma exacerbation are only partially understood. Objective To …