Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost
200,000 people worldwide each year. It is acquired when mammalian hosts inhale the …

Upon Cryptococcus neoformans infection of the host lung, the fungus enters a nutrient poor
environment and must adapt to a variety of host-specific stress conditions (temperature …

Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

The pathogenic yeast Cryptococcus neoformans produces polyploid titan cells in response
to the host lung environment that are critical for host adaptation and subsequent disease …

Upon encountering the host environment, fungal pathogens undergo morphogenic switches
to mediate immune evasion and dissemination. The Candida ablicans yeast-to-hyphal …

The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

Infection with Cryptococcus neoformans begins when desiccated yeast cells or spores are
inhaled and lodge in the alveoli of the lungs. A subset of cryptococcal cells in the lungs …

Cryptococcus neoformans, a human pathogenic fungus, infects immunocompromised
humans and causes serious diseases such as cerebral meningitis. C. neoformans controls …

Human studies have shown associations between cryptococcal meningitis and reduced IgM
memory B cell levels, and studies in IgM-and/or B cell-deficient mice have demonstrated …

In the host lung, the human fungal pathogen Cryptococcus neoformans undergoes a
morphological switch from small haploid yeast to large polyploid titan cell, contributing to C …