Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause
G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but …

The roles of the HIV1 protein Vpr in virus replication and pathogenesis remain unclear.
Expression of Vpr in dividing cells causes cell cycle arrest in G 2. Vpr also facilitates low titer …

Vpr-mediated induction of G2 cell cycle arrest has been postulated to be important for
human immunodeficiency virus type 1 (HIV-1) replication, but the precise role of Vpr in this …

HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA
replication stress. ATR activation results in cell cycle arrest in G 2 and induction of apoptosis …

ABSTRACT HIV-1 viral protein R (Vpr) induces cell cycle arrest at the G2/M phase by a
mechanism involving the activation of the DNA damage sensor ATR. We and others recently …

The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of
many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex. In so doing …

HIV-1 Viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the
ATR DNA damage/stress checkpoint. Recently, we and several other groups showed that …

How the HIV1 Vpr protein initiates the host cell response leading to cell cycle arrest in G2
has remained unknown. Here, we show that recruitment of DCAF1/VprBP by Vpr is essential …

The Vpr protein of primate lentiviruses arrests cell cycling at the G 2/M phase through an
inactivation of cyclin B–p34 cdc2 and its upstream regulator cdc25. We provide here …

The replication of viruses depends on the cell cycle status of the infected cells. Viruses have
evolved functions that alleviate restrictions imposed on their replication by the host. Vpr, an …