Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …

Isoorientin (ISO) is a flavonoid compound, and possesses a significant antioxidant potential.
However, the effects of ISO on the oxidative damage in normal hepatocytes remain …

Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …

Oxidative stress, as an important pathogenic factor, plays a critical role in acetaminophen
(APAP) overdose-induced acute liver failure (ALF). Thus, an antioxidative strategy may be a …

Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the
clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of …

Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …

Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin
exhibited potential hepatoprotective effect in our previous study. The present investigation …

Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) …

Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive
oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a …

Isoorientin (ISO) is a flavonoid compound that can be extracted from several plant species,
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …