Aims. Limited aeration has been demonstrated to cause slowdown in proliferation and
delayed budding, resulting eventually in a unique unbudded G2-arrest in the obligate …

Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …

Background: Cryptococcus neoformans is an obligate aerobic pathogenic yeast causing
lung infection typically followed by spread to the central nervous system. During …

Eukaryotic cells utilize complex signaling systems to detect their environments, responding
and adapting as new conditions arise during evolution. The basidiomycete fungus …

Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival,
and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse …

Cell wall integrity is crucial for fungal growth, development and stress survival. In the model
yeast Saccharomyces cerevisiae, the cell integrity Mpk1/Slt2 MAP kinase and calcineurin …

Due to its location, the fungal cell wall is the compartment that allows the interaction with the
environment and/or the host, playing an important role during infection as well as in different …

Cryptococcus neoformans, the etiologic agent of cryptococcosis, is an obligately aerobic
yeast that inhabits an environmental niche exposed to ambient air. The cell doubling time …

Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific
protein phosphatase that orchestrates cellular Ca2+ signaling responses. In Cryptococcus …

The ability of Cryptococcus neoformans to grow at the mammalian body temperature (37° C
to 39° C) is a well-established virulence factor. Growth of C. neoformans at this physiological …