Abnormal liver function has dramatic effects on brain functions. Hyperammonemia interferes
profoundly with brain metabolism, astrocyte volume regulation, and in particular …

There is substantial clinical and experimental evidence to suggest that ammonia toxicity is a
major factor in the pathogenesis of hepatic encephalopathy associated with subacute and …

Ammonia is a normal biochemical component of brain produced and utilized in several
reactions of nitrogen metabolism. Blood and brain ammonia levels are in dynamic …

Results of neuropathologic, spectroscopic, and neurochemical studies continue to confirm a
major role for ammonia in the pathogenesis of the central nervous system complications of …

Interference with cerebral energy metabolism due to excess ammonia has been postulated
as a cause of hepatic encephalopathy. Furthermore, consideration of the neurologic basis of …

Hepatic encephalopathy is a potentially reversible disease. Therefore, a structural
abnormality of the CNS cannot be the cause of the encephalopathy. The encephalopathy is …

The precise mechanism underlying the neurotoxicity of Hepatic Encephalopathy (HE) is
remains unclear. The dominant view has been that gut-derived nitrogenous toxins are not …

The pathogenesis of hepatic encephalopathy (HE) remains elusive. While it is clear that
ammonia is the likely toxin and that astrocytes are the main target of its neurotoxicity …

Hyperammonemia is necessary for development of the cerebral complications to liver
disease including hepatic encephalopathy and cerebral edema but the mechanisms are …

The role of ammonia in hepatic encephalopathy has never been clearly defined. We have
approached the problem by constant infusion of macaques with ammonium acetate …