Influenza A enters the host cell via interactions between its HA molecules and the terminal
sialic acid of host-cell surface glycoproteins or glycolipids. Once this binding has occurred …

M2, the spliced segment of the matrix (M) gene of influenza A virus, is an integral membrane
protein which functions as an ion channel both when the virus is in the host endosome and …

Influenza A virus strains adopt different host specificities mainly depending on their
hemagglutinin (HA) protein. Via HA, the virus binds sialic acid receptors of the host cell and …

Despite intensive study, the development of vaccines and the application of modem
structural and molecular biology, influenza virus remains a major, recurrent pathogen. In …

We tested two approaches to overcoming resistance of influenza A viruses against
adamantane derivatives. First, adamantane derivatives that interfere with the ion channel …

Both influenza A virus surface glycoproteins, the haemagglutinin (HA) and neuraminidase
(NA), interact with neuraminic acid-containing receptors. The influenza virus …

Abstract Amantadine (1-aminoadamantane hydrochloride) is effective in the prophylaxis and
treatment of influenza A infection. In tissue culture this selective, strain-specific antiviral …

Amantadine specifically inhibits the release of virus particles from cells infected with the
Rostock (H7N1) strain of influenza A virus, apparently as a consequence of a membrane …

Influenza A viruses possess two surface glycoproteins, hemagglutinin (HA), which binds to
sialic-acid-containing receptors, and neuraminidase (NA), which removes sialic acid from …

Despite recent advances in our understanding of viral structure and replication, efforts to
develop antiviral drugs have targeted the host cell machinery that is required for viral …