In the past decade, studies that provide insights into the mechanisms of action underlying
ketamine's rapid antidepressant effects have been key to identifying relevant targets for …

Objectives Sub-anesthetic doses of ketamine have been found to provide rapid
antidepressant actions, indicating that the cellular signaling systems targeted by ketamine …

Objectives Sub‐anesthetic doses of ketamine have been found to provide rapid
antidepressant actions, indicating that the cellular signaling systems targeted by ketamine …

A debilitating mental disorder, major depressive disorder is a leading cause of global
disease burden. Existing antidepressant drugs are not adequate for the majority of …

Background Clinical studies demonstrate that the N-methyl-D-aspartate (NMDA) receptor
antagonist, ketamine, induces rapid antidepressant effects in patients with refractive major …

Over the last decade, numerous controlled studies have consistently described rapid, robust,
and relatively sustained antidepressant response rates associated with single-dose …

Background Since the discovery of antidepressants, new treatments have emerged with
fewer side effects but no greater efficacy. Glycogen synthase kinase 3 β (GSK-3β), a kinase …

A single dose of the short-acting NMDA antagonist ketamine produces rapid and prolonged
antidepressant effects in treatment-resistant patients with major depressive disorder (MDD) …

Ketamine produces rapid and robust antidepressant effects in depressed patients within
hours of administration, often when traditional antidepressant compounds have failed to …

Background: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent
episodes of mania and depression. Primary mood-stabilizing drugs like lithium and …