BACKGROUND: Several studies have tried to find possible associations between genetic
polymorphisms and inflammatory bowel disease prevalence and/or phenotype. Our …

Background Interleukin 1 (IL‐1) and its physiological antagonist interleukin‐1 receptor
antagonist (IL‐1ra) play a crucial role in the pathogenesis of inflammatory bowel disease …

Background—An imbalance between the proinflammatory cytokine interleukin 1β (IL-1β)
and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) has been postulated as …

Abstract Background and Aim Interleukin (IL)-1 family members play an important role in the
pathogenesis of inflammatory bowel disease (IBD). There are conflicting results regarding …

There is evidence of a disbalance in the inflammatory regulation of patients with
inflammatory bowel diseases (IBD). Interleukin-1β plays an important role in the pro …

Background & Aims: The role of the interleukin (IL)-1 receptor antagonist (IL-1ra) in
predisposing an individual to inflammatory bowel disease (IBD) is controversial. This study …

Background: There is growing evidence of the importance of genetic predisposition and the
activation of the mucosal immune system in the pathogenesis of inflammatory bowel …

Objective: Genetic susceptibility to inflammatory bowel disease is well recognized. There is
also increasing evidence for the activation of the mucosal immune system and the …

1. Introduction. Multiple cytokines have been studied for their role in the propagation of the
inflammatory process related to inflammatory bowel diseases (IBD), but the role of …

Background: Inflammatory bowel disease (IBD) is a chronic inflammation of the
gastrointestinal tract of unknown aetiology, phenotypically categorized into ulcerative colitis …