Abstract CRISPR-associated Rossmann Fold (CARF) and S MODS-a ssociated and fused to
v arious e ffector d omains (SAVED) are key components of c yclic oligonucleotide-b ased a …

Highlights•Type III is the most diverse and complex CRISPR-Cas system.•Type III CRISPR-
Cas systems cleave RNA and DNA.•The effector complexes generate secondary …

Abstract Type III CRISPR-Cas loci encode some of the most abundant, yet complex, immune
systems of prokaryotes. They are composed of a Cas10 complex that uses an RNA guide to …

Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic
Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second …

CRISPR loci and Cas proteins provide adaptive immunity in prokaryotes against invading
bacteriophages and plasmids. In response, bacteriophages have evolved a broad spectrum …

CRISPR systems are widespread in the prokaryotic world, providing adaptive immunity
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …

The CRISPR system provides adaptive immunity against mobile genetic elements in
prokaryotes. On binding invading RNA species, Type III CRISPR systems generate cyclic …

Abstract Type III CRISPR–Cas prokaryotic immune systems provide anti-viral and anti-
plasmid immunity via a dual mechanism of RNA and DNA destruction. Upon target RNA …

Type III CRISPR–Cas systems make use of a multi-subunit effector complex to target foreign
(m) RNA transcripts complementary to the guide/CRISPR RNA (crRNA). Base-pairing of the …

The CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-
associated) adaptive immune systems use small guide RNAs, the CRISPR RNAs (crRNAs) …