BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

[HTML][HTML] BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - Elsevier
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …

[PDF][PDF] BRAF mutation in thyroid cancer

M Xing - Endocrine-related cancer, 2005 - researchgate.net
Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon
which novel approaches to the management of thyroid cancer can be developed. A recent …

Prognostic utility of BRAF mutation in papillary thyroid cancer

M Xing - Molecular and cellular endocrinology, 2010 - Elsevier
Papillary thyroid cancer (PTC) is a common endocrine malignancy that frequently harbors
the oncogenic T1799A BRAF mutation. As a novel prognostic molecular marker, this …

BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer

M Xing, WH Westra, RP Tufano, Y Cohen… - The Journal of …, 2005 - academic.oup.com
Context: Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve
risk stratification of this cancer. Objective: The objective of the study was to investigate the …

Clinical implications of BRAF mutation in thyroid carcinoma

E Puxeddu, C Durante, N Avenia, S Filetti… - Trends in Endocrinology …, 2008 - cell.com
Significant progress has recently been made in the clinical management of papillary thyroid
carcinoma. The accuracy of diagnosis and prognostic stratification of this type of carcinoma …

Clinicopathologic Implications of the BRAFV600E Mutation in Papillary Thyroid Cancer: A Subgroup Analysis of 3130 Cases in a Single Center

JY Lim, SW Hong, YS Lee, BW Kim, CS Park… - Thyroid, 2013 - liebertpub.com
Background: The BRAF mutation has been shown to be associated with aggressive
clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies …

Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma

C Lupi, R Giannini, C Ugolini, A Proietti… - The Journal of …, 2007 - academic.oup.com
Context: Because very few studies have examined the correlation between BRAF mutations
and clinicopathological features of papillary thyroid carcinoma (PTC), we analyzed here a …

BRAF T1796A Transversion Mutation in Various Thyroid Neoplasms

M Xing, V Vasko, G Tallini, A Larin, G Wu… - The Journal of …, 2004 - academic.oup.com
A high prevalence of activating mutation of the B type Raf kinase (BRAF) gene was recently
reported in papillary thyroid cancer (PTC). However, the frequency of this mutation in several …

Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma

O Koperek, C Kornauth, D Capper… - The American journal …, 2012 - journals.lww.com
The V600E mutation of the B-type Raf kinase (BRAF) gene is a common event in papillary
thyroid carcinoma (PTC) and seems to play a key role in the development and progression …