Type 1 diabetes in humans is a serious autoimmune disorder of children that is still poorly
understood, unpreventable, and irreversible. Study of its animal models, notably the NOD …

Despite decades of research using various animal models for type 1 diabetes, we are still
struggling to define the initiating autoantigens, the precise mechanisms of β cell destruction …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes
mellitus shares multiple characteristics with the human disease, and studies employing this …

The use of animal models to study diseases is fundamental to the advancement of the
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …

T1D (Type 1 diabetes) is an autoimmune disease caused by the immune-mediated
destruction of pancreatic β-cells. Studies in T1D patients have been limited by the …

Type 1 diabetes results from a genetically and immunologically complex autoimmune
process that is specifically directed against the pancreatic beta cells. Non-obese diabetic …

Despite decades of research in humans and mouse models of disease, substantial gaps
remain in our understanding of pathogenic mechanisms underlying the development of type …

Abstract Type 1 diabetes (T1D) occurs when the immune system attacks the insulin‐
producing beta cells located in the islets of Langerhans within the pancreas. Animal models …

For more than 35 years, the NOD mouse has been the primary animal model for studying
autoimmune diabetes. During this time, striking similarities to the human disease have been …