The TAM receptor protein tyrosine kinases—Tyro3, Axl, and Mer—are essential regulators of
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …

Simple Summary TAM receptors are a family of receptor tyrosine kinases, comprising Tyro3,
Axl and MerTK. Their primary role is in digestion of dying cells by macrophages without …

The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

Receptor tyrosine kinases (RTKs) regulate cellular processes by converting signals from the
extracellular environment to the cytoplasm and nucleus. Tyro3, Axl, and Mer (TAM) receptors …

The TAM family of receptors (ie, Tyro3, Axl, and Mertk), and their ligands Growth arrest
specific factor 6 (Gas6) and Protein S (Pros1) contribute to several oncogenic processes …

Abstract The TAM receptors—TYRO3, AXL, MERTK—are pleiotropically expressed
receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) …

The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

The TAM receptor family of TYRO3, AXL and MERTK regulates tissue and immune
homeostasis. Aberrant TAM receptor signalling has been linked to a range of diseases …

Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Abstract Tyro3, Axl and Mertk are members of the TAM family of tyrosine kinase receptors.
TAMs are activated by two structurally homologous ligands GAS6 and PROS1. TAM …