Functional polymorphisms in the dopamine transporter gene (DAT1 or SLC6A3) modulate
responsiveness to salient stimuli, such that carriers of one 9R-allele of DAT1 (compared with …

Objective The aim of this study was to identify gene variants of DAT1 (SLC6A3) that
modulate subjective responses to acute cocaine exposure. Methods Non-treatment-seeking …

The dopamine (DA) transporter DAT1 is a major target bound by cocaine in brain. We
examined the influence of functional genetic variants in DAT1 on cocaine addiction. Repeat …

BACKGROUND: Addictive disorders are heritable, but the search for candidate functional
polymorphisms playing an etiological role in addiction is hindered by complexity of the …

Rationale Alcohol dependence is characterized by the development of tolerance, withdrawal
symptoms, and craving for alcohol. Chronic alcohol consumption causes neuroadaptive …

Background and Objectives Disulfiram has been beneficial in treating cocaine addiction in
several studies. Patients with two SLC6A3 (DAT1) rs28363170 10‐repeat alleles who have …

Cocaine abuse disrupts dopamine system function, and reduces cocaine inhibition of the
dopamine transporter (DAT), which results in tolerance. Although tolerance is a hallmark of …

The dopamine transporter (DAT) is a principal regulator of dopaminergic neurotransmission
and its gene (the SLC6A3) is a strong biological candidate gene for various behavioral-and …

Epistatic gene–gene interactions could contribute to the heritability of complex multigenic
disorders, but few examples have been reported. Here, we focus on the role of aberrant …

Individual variability in responses to stimulant drugs may influence risk of stimulant abuse
and treatment response. However, the genetic determinants of this variability have yet to be …