The reinforcing efficacy of cocaine is largely determined by its capacity to inhibit the
dopamine transporter (DAT), and emerging evidence suggests that differences in cocaine …

Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …

A major theme of addiction research has focused on the neural substrates of individual
differences in the risk for addiction; however, little is known about how vulnerable …

Cocaine abuse disrupts dopamine system function, and reduces cocaine inhibition of the
dopamine transporter (DAT), which results in tolerance. Although tolerance is a hallmark of …

Cocaine addiction is a debilitating neuropsychiatric disorder characterized by uncontrolled
cocaine intake, which is thought to be driven, at least in part, by cocaine-induced deficits in …

Cocaine blocks the normal role of the dopamine transporter (DAT) in terminating dopamine
signaling through molecular interactions that are only partially understood. Cocaine analog …

Cocaine is a commonly abused central nervous system stimulant that enhances dopamine
(DA) neurotransmission through its ability to block dopamine transporters (DAT s). Recent …

Cocaine's main pharmacological actions are the inhibition of the dopamine, serotonin, and
norepinephrine transporters. Its main behavioral effects are reward and locomotor …

There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the
serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies …

Cocaine primarily exerts its behavioral effects by enhancing dopaminergic
neurotransmission, amplifying dopamine-encoded sensorimotor integration. The presumed …