Background: Sympathetic denervation of the heart is frequent in patients with sporadic and
genetic synucleinopathies. In 2004, we described a new mutation in the synuclein gene …

OBJECTIVE: The aim of this study was to analyze autonomic function and cardiac
sympathetic innervation in symptomatic and asymptomatic carriers of the E46K alpha …

Introduction Here we report the case of an asymptomatic carrier of the E46K substitution in α-
synuclein gene where we have documented that cardiac sympathetic denervation precedes …

Introduction Parkinson disease (PD), pure autonomic failure (PAF), and multiple system
atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein …

Misfolding of alpha-synuclein (aSyn), formation of toxic oligomers, and their prion like
spread are considered key mechanisms of disease pathogenesis in multiple system atrophy …

Objective Lewy body (LB) synucleinopathies such as Parkinson's disease (PD) entail
profound cardiac norepinephrine deficiency. The status of sympathetic noradrenergic …

Publisher Summary This chapter explains how sympathetic imaging provides an important
supplement to physiological, neurochemical, and neuropharmacological approaches in the …

Synuclein (α, β, and γ) proteins are highly expressed in presynaptic terminals, and
significant data exist supporting their role in regulating neurotransmitter release. Targeting …

Background Autonomic synucleinopathies feature deposition of the protein alpha-synuclein
(AS) in neurons [eg, Lewy body neurogenic orthostatic hypotension (nOH)] or glial cells …

Abnormal aggregates of alpha-synuclein (α-syn) in the nervous system are the
neuropathological hallmark of the synucleinopathies. Based on autopsy studies, we know …