The potency of conventional inhaled anesthetics increases with maturation: the 50%
effective dose (minimum alveolar anesthetic concentration [MAC]) for conventional inhaled …

The potency of conventional inhaled anesthetics increases with increasing age: the 50%
effective dose (minimum alveolar anesthetic concentration [MAC]) for anesthesia in the …

In this study, we measured the minimum alveolar anesthetic concentration (MAC) in several
mouse strains, including strains used in the construction of genetically engineered mice …

We measured the naturally occurring variability in anesthetic potency, defined by the
minimum alveolar anesthetic concentrations (MACs) of inhaled anesthetics required to …

Anaesthetic requirements for nitrous oxide, enflurane and isoflurane were determined in
mice selectively bred for their susceptibility (“long-sleep” mice) or resistance (“short-sleep” …

Intoxication with alcohols can produce anesthesia. In contrast, chronic ethanol consumption
can produce tolerance to inhaled and other general anesthetics. We tested whether ongoing …

A high number of trauma patients are under the influence of alcohol. Since many of them
need immediate surgical procedures, it is imperative to be aware of the interaction of alcohol …

BACKGROUND: While studying neurotoxicity in rats, we observed that the anesthetic
minimum alveolar anesthetic concentration (MAC) of isoflurane decreases with increasing …

A selective breeding process designed to produce mice resistant (HI mice) and susceptible
(LO mice) to nitrous oxide anesthesia was continued through 10 generations. At the tenth …

UNDERSTANDING how anesthetics act requires a synthesis of information from in vitro
(molecular, receptor, and neuronal systems) and in vivo (whole animal) studies. Most …