Acinetobacter baumannii is a multi‐drug resistant, Gram‐negative bacteria and infection
with this organism is one of the major causes of mortality in intensive care units …

The opportunistic Gram-negative bacterium Acinetobacter baumannii (AB) is a leading
cause of life-threatening nosocomial pneumonia. Outbreaks of multidrug resistant (MDR)-AB …

Activation of caspase-11 by some Gram-negative bacteria triggers the caspase-1/interleukin
1β (IL-1β) pathway, independent of canonical inflammasomes. Acinetobacter baumannii is a …

Background The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3)
inflammasomes are intracellular protein complexes that orchestrate immune responses …

Assembly of the inflammasome has recently been identified to be a critical event in the
initiation of inflammation. However, its role in bacterial killing remains unclear. Our study …

Bacterial flagellin is critical to mediate NLRC4 inflammasome-dependent caspase-1
activation. However, Shigella flexneri, a nonflagellated bacterium, and a flagellin (fliC) …

The inflammasome is a key factor in innate immunity and senses soluble pathogen and
danger-associated molecular patterns as well as biological crystals (urate, cholesterol, etc.) …

Sterile lung injury is an important clinical problem that complicates the course of severely ill
patients. Interruption of blood flow, namely ischemia–reperfusion (IR), initiates a sterile …

Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to
inflammation and remote organ damage. The NLRP3 inflammasome regulates the caspase …

Abstract Acinetobacter baumannii (A. baumannii), one of the major pathogens that causes
severe nosocomial infections, is characterised by a high prevalence of drug resistance. It …