Gap junction–mediated intercellular coupling is higher in the equatorial region of the lens
than at either pole, a property believed to be essential for lens transparency. We show that …

Gap junction–mediated intercellular communication (GJIC) is essential for the proper
function of many organs, including the lens. GJIC in lens epithelial cells is increased by FGF …

Homeostasis in the lens is dependent on an extensive network of cell-to-cell gap junctional
channels. Gap junction-mediated intercellular coupling (GJIC) is higher in the equatorial …

The cells of the lens are joined by an extensive network of gap junction intercellular
channels consisting of connexins 43, 46, and 50. We have proposed, and experimentally …

The cells of the vertebrate lens are linked to each other by gap junctions, clusters of
intercellular channels that mediate the direct transfer of low-molecular-weight substances …

A major limitation in lens gap junction research has been the lack of experimentally tractable
ex vivo systems to study the formation and regulation of fiber-type gap junctions. Although …

Fibroblast growth factors (FGFs) play a central role in two processes essential for lens
transparency—fiber cell differentiation and gap junction–mediated intercellular …

The lens is an avascular organ in which gap junctions play a pivotal role for cell physiology
and transparency. Here we evaluate a lens culture system as a model for studies of lens gap …

purpose. The present study was undertaken to explore the roles gap junctions play in lens
epithelial cell differentiation. methods. Recombinant retroviruses expressing three chick lens …

Results of electrical, dye-coupling and morphological studies have previously suggested
that gap junctions mediate communication between the anterior epithelium of the lens and …