Pyramidal neuron dendrites integrate synaptic input from multiple partners. Different inputs
converging on the same dendrite have distinct structural and functional features, but the …

Individual axons of central neurons innervate a large number of distinct postsynaptic targets
belonging to divergent functional categories such as glutamatergic principal cells and …

Network activity homeostatically alters synaptic efficacy to constrain neuronal output.
However, it is unclear how such compensatory adaptations coexist with synaptic information …

G-protein-coupled receptor 158 (Gpr158) is highly expressed in striatum, hippocampus and
prefrontal cortex. It gained attention as it was implicated in physiological responses to stress …

Hippocampal CA3 neurons form synapses with CA1 neurons in two layers, stratum oriens
(SO) and stratum radiatum (SR). Each layer develops unique synaptic properties but …

Factors that regulate the formation, spatial patterning, and maturation of CNS synapses are
poorly understood. We used organotypic hippocampal slice cultures derived from …

In the central nervous system, several forms of experience-dependent plasticity, learning
and memory require the activity-dependent control of synaptic efficacy. Despite substantial …

Synapses are the key elements for signal processing and plasticity in the brain. They are
composed of nearly the same structural subelements, an apposition zone including a pre …

The hippocampus mediates several higher brain functions, such as learning, memory, and
spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role …

Recent advances in imaging technology have highlighted that scaffold proteins and
receptors are arranged in subsynaptic nanodomains. The synaptic membrane-associated …