Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member
of sirtuin family, plays a dual role either in cancer promotion or suppression. There is no …

The phytoalexin resveratrol has been described to have chemopreventive and
chemotherapeutic effects in several tumor models while its effects on osteosarcoma have …

Abstract Sirtuin-1 (SIRT1) possesses apparently dual roles in regulation of tumor. Previous
reports have documented the crosstalk between SIRT1 with signal transducer and activator …

SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating
histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor …

Osteoarthritis (OA) has become a major public health problem with the increased aging
population. Previous studies have demonstrated that resveratrol (RES) was able to increase …

Sirt 1 plays a critical role in stress responses. We determined the deregulation of Sirt 1
activity, p53 acetylation, Bcl-2 expression, and mitochondria-dependent apoptosis in mouse …

It is still a controversy whether the role of Sirtuin 7 (SIRT7) is an oncogene or a tumor
suppressor gene in cancer as SIRT7 may have different functions in different types of …

Scope: Understanding the molecular mechanisms through which natural products and
dietary supplements exhibit anticancer properties is crucial and can lead to drug discovery …

Sirtuins, NAD+-dependent deacetylases, could target both histones and nonhistone proteins
in mammalian cells. Sirt1 is the major sirtuin and has been shown to involve various cellular …

Introduction P53 represents a key player in apoptosis-induction in cancers including
colorectal cancer (CRC) that ranks third worldwide in cancer prevalence as well as mortality …