Antitumor agents that bind to tubulin and disrupt microtubule dynamics have attracted
considerable attention in the last few years. To extend our knowledge of the thiazole ring as …

Combretastatin A-4, a potent tubulin polymerization inhibitor, caused us to synthesize a
novel series of 2-amino-4-(3′, 4′, 5′-trimethoxyphenyl)-5-aryl thiazoles with the goal of …

Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of
a series of N-(6-substituted benzothiazol-2-yl)-2-[(5-(arylamino)-1, 3, 4-thiadiazol-2-yl) thio] …

A series of cis-restricted 1, 5-disubstituted 1, 2, 3-triazole analogues of combretastatin A-4
(1) have been prepared. The triazole 12f, 2-methoxy-5-(1-(3, 4, 5-trimethoxyphenyl)-1H-1, 2 …

Antimitotic agents that interfere with microtubule formation are one of the major classes of
cytotoxic drugs for cancer treatment. Multiple 2-methyl-4-(3′, 4′, 5′-trimethoxyphenyl)-5 …

A new series of tubulin polymerization inhibitors based on the 2-aryl/heteroaryl-4-amino-5-
(3′, 4′, 5′-trimethoxybenzoyl) thiazole scaffold was synthesized and evaluated for …

During recent years, small molecules containing five-member heterocyclic moieties have
become the subject of considerable growing interest for designing new antitumor agents …

Diarylisoxazoles are potent antiproliferative tubulin-targeting agents. Their isomeric 3, 4-
diaryl-5-unsubstituted isoxazoles are hardly accessible. The synthesis of 3, 4-diaryl-5 …

Abstract New bis-thiazole derivatives (1–10) were synthesized via the ring closure of 1, 1′-
(3, 3′-dimethoxybiphenyl-4, 4′-diyl) bis (thiourea) with phenacyl bromides and evaluated …

Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid [2-(cyclohexanecarbonylamino)
benzothiazol-6-yl] amide (1), which shows selective cytotoxicity against tumorigenic cell …