Abstract Human class II MHC Ag are a family of cell surface glycoproteins. Their constitutive
expression is limited to B lymphocytes and thymic epithelial cells. In many other cells their …

Regulatory factor X (RFX) is a transcription factor that binds the conserved X1 box of MHC
class II promoters and is essential for transcription of class II genes. The subunit structure of …

The 5'flanking region of the mig gene, a member of the chemokine family of small mw
chemoattractant and growth regulatory factors, contains an IFN-gamma-responsive …

Interferon gamma (IFN-gamma) is a potent inducer of major histocompatibility complex
(MHC) antigens during normal immune responses and in abnormal responses in …

The purpose of this review is to provide an interpretative view of work from our laboratory on
the DRA gene, and incorporate it with work from other laboratories. Specially, we will deal …

The transcription factor, NF-Y, plays a critical role in tissue-specific major histocompatibility
complex class II gene transcription. In this report the biochemical properties of the …

Transcriptional regulation of the human major histocompatibility complex class II genes
requires at least two upstream elements, the X and Y boxes, located in the-50-to-150-base …

We have cloned the RAG-1 promoter region and have determined that almost all detectable
promoter activity resides within a 208-bp fragment. Sequence analysis of this promoter …

Major histocompatibility complex (MHC) class II molecules present exogenous antigenic pep
tides to CD4-positive helper T lymphocytes, and regulation of their expression is thus an …

A previously unrecognized element, located downstream of the start site of transcription in
the first exon of the DR alpha gene, has been defined that enhances promoter activity up to …