Under normoxic conditions the alpha-subunit of hypoxia-inducible factor (HIF-1α) protein is
targeted for degradation by the von Hippel-Lindau (VHL) tumor suppressor protein acting as …

In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …

Hypoxia-inducible factor 1α (HIF-1α) is rapidly degraded by the ubiquitin-proteasome
pathway under normoxic conditions. Ubiquitination of HIF-1α is mediated by interaction with …

The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …

Under normoxic conditions the hypoxia-inducible factor-1α (HIF-1α) protein is targeted for
degradation by the von Hippel-Lindau (pVHL) tumor suppressor protein acting as an E3 …

The hypoxia-inducible factor (HIF) is recognized as the master regulator of hypoxia
response. HIF-α subunits expression are tightly regulated. In this study, our data show that …

The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive
cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is …

Hypoxia-inducible factor 1 (HIF-1) is controlled through stability regulation of its alpha
subunit, which is expressed under hypoxia but degraded under normoxia. Degradation of …

The transcriptional activator complex HIF-1 plays a key role in the long term adaptation of
cells and tissues to their hypoxic microenvironment by stimulating the expression of genes …

Adaptive responses to hypoxia are essential for the survival of all organisms. Under hypoxic
conditions, the transcription of a large group of genes relevant for oxygen homeostasis is …