Venous valves play a crucial role in blood circulation, promoting the one-way movement of
blood from superficial and deep veins towards the heart. By preventing retrograde flow …

Intraluminal valves are required for the proper function of lymphatic collecting vessels and
large lymphatic trunks like the thoracic duct. Despite recent progress in the study of …

Venous valves (VVs) are critical for unidirectional blood flow from superficial and deep veins
towards the heart. Congenital valve aplasia or agenesis may, in some cases, be a direct …

Lymphatic valves (LVs) are cusped luminal structures that permit the movement of lymph in
only one direction and are therefore critical for proper lymphatic vessel function. Congenital …

Cells within the vascular wall are coupled by gap junctions, allowing for direct intercellular
transfer of low molecular weight molecules. Although gap junctions are believed to be …

Mice lacking both connexin37 (Cx37) and connexin40 (Cx40), gap junction proteins
expressed in vascular endothelium, die perinatally with pronounced vascular abnormalities …

In order to study the specific function of connexin-26 (Cx26, also known as gap junction beta-
2 protein; Gjb2), we generated knockin mice that expressed either a floxed lacZ reporter or …

In order to reveal the biological function (s) of the gap-junction protein connexin 45 (Cx45),
we generated Cx45-deficient mice with targeted replacement of the Cx45-coding region with …

Abstract Connexin37 (Cx37) forms intercellular channels between endothelial cells (EC),
and contributes to coordinate the motor tone of vessels. We investigated the contribution of …

Gap junctions are composed of connexin (Cx) proteins and mediate intercellular
communication required for many developmental and physiological processes. Here we …