Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin

J Handzlik, E Szymańska, S Alibert, J Chevalier… - Bioorganic & medicinal …, 2013 - Elsevier
A series of amine-alkyl derivatives of 5-arylidenehydantoin 3–21 was evaluated for their
ability to improve antibiotic effectiveness in two strains of Gram-negative Enterobacter …

Amine–alkyl derivatives of hydantoin: New tool to combat resistant bacteria

J Handzlik, E Szymańska, J Chevalier… - European journal of …, 2011 - Elsevier
A series of new 5, 5-diphenylhydantoin derivatives with various amine–alkyl terminal
fragments at N1-position were synthesized. Then a series of twenty-eight compounds with …

[HTML][HTML] Efflux pump blockers in Gram-negative bacteria: The new generation of hydantoin based-modulators to improve antibiotic activity

E Otręebska-Machaj, J Chevalier, J Handzlik… - Frontiers in …, 2016 - frontiersin.org
Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of
new active antibiotic agents. Among effective mechanisms that contribute to the spread of …

Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant …

J Chevalier, A Mahamoud, M Baitiche, E Adam… - International journal of …, 2010 - Elsevier
Amongst the three series of quinazoline derivatives synthesised and studied in this work,
some molecules increase the antibiotic susceptibility of Gram-negative bacteria presenting …

[HTML][HTML] Molecular insights into an antibiotic enhancer action of new morpholine-containing 5-arylideneimidazolones in the fight against MDR bacteria

A Kaczor, K Witek, S Podlewska, V Sinou… - International Journal of …, 2021 - mdpi.com
In the search for an effective strategy to overcome antimicrobial resistance, a series of new
morpholine-containing 5-arylideneimidazolones differing within either the amine moiety or at …

Synergy Potential of Indole Alkaloids and Its Derivative against Drug‐resistant Escherichia coli

GR Dwivedi, S Gupta, A Maurya… - Chemical Biology & …, 2015 - Wiley Online Library
Antibacterial and synergy potential of naturally occurring indole alkaloids (IA): 10‐methoxy
tetrahydroalstonine (1), isoreserpiline (2), 10 and 11 demethoxyreserpiline (3), reserpiline …

Design and synthesis of novel arylurea derivatives of aryloxy (1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive …

V Canale, J Czekajewska, K Klesiewicz… - European Journal of …, 2023 - Elsevier
The alarming increase in the resistance of bacteria to the currently available antibiotics
necessitates the development of new effective antimicrobial agents that are active against …

New Ianthelliformisamine derivatives as antibiotic enhancers against resistant Gram-negative bacteria

C Pieri, D Borselli, C Di Giorgio, M De Meo… - Journal of medicinal …, 2014 - ACS Publications
A series consisting of ianthelliformisamimes A, B, and C as well as its synthetic analogues
was prepared in high chemical yield, from 27 to 91%, using peptide coupling as the key …

4‐Hydroxy‐α‐Tetralone and its Derivative as Drug Resistance Reversal Agents in Multi Drug Resistant Escherichia coli

GR Dwivedi, HC Upadhyay, DK Yadav… - Chemical Biology & …, 2014 - Wiley Online Library
The purpose of present investigation was to understand the drug resistance reversal
mechanism of 4‐hydroxy‐α‐tetralone (1) isolated from Ammannia spp. along with its semi …

[HTML][HTML] 5-arylideneimidazolones with amine at position 3 as potential antibiotic adjuvants against multidrug resistant bacteria

A Kaczor, K Witek, S Podlewska, J Czekajewska… - Molecules, 2019 - mdpi.com
Searching for new chemosensitizers of bacterial multidrug resistance (MDR), chemical
modifications of (Z)-5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3H-imidazol-4 (5H) …