[HTML][HTML] GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
C Terao, Y Momozawa, K Ishigaki, E Kawakami… - Nature …, 2019 - nature.com
Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …
Genetic predisposition to mosaic Y chromosome loss in blood
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …
[HTML][HTML] Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells
Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in
hematopoietic cells in men. However, due to the high prevalence of LOY as the sole …
hematopoietic cells in men. However, due to the high prevalence of LOY as the sole …
[HTML][HTML] Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
[HTML][HTML] GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
Mosaic loss of chromosome Y (LOY) in leukocytes is the most common form of clonal
mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways …
mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways …
[HTML][HTML] Loss of Y and clonal hematopoiesis in blood—two sides of the same coin?
V Ljungström, J Mattisson, J Halvardson, T Pandzic… - Leukemia, 2022 - nature.com
Studies in recent years have revealed that increasing age is associated with the
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …
accumulation of post-zygotic genetic aberrations in different cell lineages even in the …
[HTML][HTML] Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
M Danielsson, J Halvardson, H Davies… - European Journal of …, 2020 - nature.com
Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …
associated with increased risk for all-cause mortality, various forms of cancer and …
Mosaic Y loss is moderately associated with solid tumor risk
Mosaic loss of the Y chromosome (mLOY) in peripheral leukocytes is a somatic event in
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …
which a fraction of leukocytes have lost the entire Y chromosome. The frequency of mLOY …
[HTML][HTML] Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …