The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …

Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …

Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Background Intratumoral hypoxia and epithelial–mesenchymal transition are involved in
tumor invasion and metastasis. Aims This study investigated the molecular mechanisms that …

Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …

Tumor hypoxia has been reported to induce tumor progression in several carcinomas.
Current studies have shown that hypoxia inducible factor-1α (HIF-1α) is stabilized under …

Hypoxic and stroma-rich microenvironments, characteristic features of pancreatic cancers,
are strongly associated with a poor prognosis. However, whether and how hypoxia …

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's
research team made many efforts on revealing the oncogenic function of hypoxic inducible …