Epoxyeicosatrienoic acids (EETs) are endothelium-derived arachidonic acid metabolites of
cytochrome P450. They dilate coronary arteries, open K+ channels, and hyperpolarize …

Epoxyeicosatrienoic acids (EETs) cause vascular relaxation by activating smooth muscle
large conductance Ca2+-activated K+ (KCa) channels. EETs are metabolized to …

1 Epoxyeicosatrienoic acids (EETs) have been described as endothelium‐derived hyper‐
polarizing factors (EDHFs), based on their stimulatory effects on smooth muscle K+ …

Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-
derived hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive …

Epoxyeicosatrienoic acids (EETs), the cytochrome P-450 epoxygenase metabolites of
arachidonic acid, are candidates of endothelium-derived hyperpolarizing factors. We have …

Epoxyeicosatrienoic acids (EETs) are released from endothelial cells and potently dilate
small arteries by hyperpolarizing vascular myocytes. In the present study, we investigated …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450
monooxygenase, which are released from endothelial cells and dilate arteries. Dilation …

Arachidonic acid can be oxidatively metabolized by cytochrome P450 epoxygenase to four
regioisomeric epoxyeichosatrienoic acids (5, 6-; 8, 9-; 11, 12-; 14, 15-EET), which exhibit …

Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase
metabolism of arachidonic acid, can regulate the activity of ion channels. We examined the …

Epoxyeicosatrienoic acids (EETs) are cytochrome P450–derived metabolites of arachidonic
acid. They are potent endogenous vasodilator compounds produced by vascular cells, and …