Putative role of proteolysis and inflammatory response in the toxicity of nerve and blister chemical warfare agents: implications for multi‐threat medical …

FM Cowan, CA Broomfield, DE Lenz… - Journal of applied …, 2003 - Wiley Online Library
Despite the contrasts in chemistry and toxicity, for blister and nerve chemical warfare agents
there may be some analogous proteolytic and inflammatory mediators and pathological …

Toxicology of chemical warfare agents

RL Maynard, RP Chilcott - General, Applied and Systems …, 2009 - Wiley Online Library
Irritant or toxic chemicals have been used in warfare since ancient times and a number of
international laws have attempted to prevent the use of such weapons. However, chemical …

Suppression of sulfur mustard-increased IL-8 in human keratinocyte cell cultures by serine protease inhibitors: implications for toxicity and medical countermeasures

FM Cowan, CA Broomfield, WJ Smith - Cell biology and toxicology, 2002 - Springer
The toxicity of the chemical warfare blistering agent sulfur mustard (2, 2'-dichlorodiethyl
sulfide; SM) has been investigated for nearly a century; however, the toxicological …

Therapeutic options to treat sulfur mustard poisoning—The road ahead

WJ Smith - Toxicology, 2009 - Elsevier
For the past 15 years the international research community has conducted a basic and
applied research program aimed at identifying a medical countermeasure against chemical …

Vesicant agents and antivesicant medical countermeasures: clinical toxicology and psychological implications

WJ Smith - Chemical Warfare and Chemical Terrorism, 2014 - taylorfrancis.com
The ability of vesicant agents to produce debilitating cutaneous blisters, respiratory
problems, and acute visual impairment is well recognized. The primary medical care …

(06) Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning

G Amitai, R Adani, E Fishbein, H Meshulam… - Chemico-Biological …, 2005 - Elsevier
Studies cited by Cowan et al.[J. Appl. Toxicol. 23, 177 (2003)] indicate existence of
inflammatory and cholinergic pathways in both nerve agents and sulfur mustard (HD) injury …

Medical countermeasures and other therapeutic strategies for sulfur mustard toxicity

R Vijayaraghavan, A Gautam, M Sharma - Handbook of toxicology of …, 2009 - Elsevier
Publisher Summary Chemically, sulfur mustard (SM) is bis (2-chloroethyl) sulfide and is well
known as mustard gas. There are various mustard agents. However, SM is one of the most …

Chemical warfare agents: Their past and continuing threat and evolving therapies part I of II

S Kathleen J, S Henry - SKINmed: Dermatology for the …, 2003 - Wiley Online Library
Chemical warfare agents are potentially accessible to even underdeveloped nations
because they are easily and inexpensively produced. This means that they are ideal for use …

Blister agents

RA Young, CB Bast - Handbook of toxicology of chemical warfare agents, 2020 - Elsevier
Blister agents (sulfur mustards, lewisite, and nitrogen mustards) are chemicals that cause
severe damage to the skin. Developed as chemical warfare agents, their biological activity is …

Chemical Warfare Agents Chemical Warfare Agents: Their Past and Continuing Threat and Evolving Therapies Part II of II

KJ Smith, H Skelton - SKINmed: Dermatology for the Clinician, 2003 - Wiley Online Library
Chemical warfare agents are ideal weapons for terrorists and for use in military operations
against both civilian populations and troops. Thus, there have been efforts by the United …