As a model to investigate the mechanism of caspase activation we have analysed the
processing of pro-caspase-7 by serine proteases with varied specificities. The caspase-7 …

Members of the caspase family of cysteine proteases coordinate the highly disparate
processes of apoptosis and inflammation. However, although hundreds of substrates for the …

The apoptotic cysteine protease, caspase-3, is expressed in cells as an inactive 32-kDa
precursor from which 17 kDa (p17) and 12 kDa (p12) subunits of the mature caspase-3 are …

The activation of caspase-3 represents a critical step in the pathways leading to the
biochemical and morphological changes that underlie apoptosis. Upon induction of …

Many protein substrates of caspases are cleaved at noncanonical sites in comparison to the
recognition motifs reported for the three caspase subgroups. To provide insight into the …

Caspase-12 is a dominant-negative regulator of caspase-1 (IL-1β-converting enzyme) and
an attenuator of cytokine responsiveness to septic infections. This molecular role for …

Caspase stands for cysteine-dependent aspartate specific protease, and is a term coined to
define proteases related to interleukin 1β converting enzyme and CED-3.* Thus their …

Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream
executioner caspase-3 is a physiological target. Caspases are cysteine proteases that are …

On stimulation by the Fas ligand, the death receptor, Fas, initiates a signal leading to
apoptotic cell death. Fas plays an important role in physiological cell death and is closely …

Caspases are cysteine proteases that are key effectors in apoptotic cell death. Currently,
there is a lack of tools that can be used to monitor the regulation of specific caspases in the …