Renal fibrosis is a common consequence of unilateral ureteral obstruction, which provides a
useful model to investigate the pathogenesis of obstructive nephropathy and progressive …

Renal fibrosis is characterized by accumulation of extracellular matrix components and
collagen deposition. TGF-β1 acts as a master switch promoting renal fibrosis through Smad …

Background/Aims: Consequences of obstructive nephropathy include tissue fibrosis, a major
pathophysiological mechanism contributing to development of end-stage renal disease …

Renal fibrosis is the final common pathway of chronic kidney disease (CKD), and no
effective medication is available clinically for managing its progression. Metformin was …

Renal fibrosis, a common feature of chronic kidney disease, causes the progressive loss of
renal function, in which TGF-β 1 plays a critical role. In this study, we found that expression …

Abstract TGF-β1, via Smad-dependent or Smad-independent signaling, has a central role in
the pathogenesis of renal fibrosis. This pathway has been recognized as a potential target …

Background Renal fibrosis is a frequently occurring type of chronic kidney disease that can
cause end-stage renal disease. It has been verified that emodin or HGF can inhibit the …

It is well-known that all progressive chronic kidney disease (CKD) is pathologically
characterized by tubulointerstitial fibrosis process. Multiple studies have shown the critical …

Background Transforming growth factor ß1 (TGF-ß1), connective tissue growth factor (CTGF)
and Smad7 are potent components of fibrogenesis-related signal transduction pathways …

Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and
transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating …