Design and optimization of quadruplex-specific small molecules is developing into an
attractive strategy for anti-cancer therapeutics with some promising candidates in clinical …

G-Quadruplex DNA has been recognized as a highly appealing target for the development
of new selective chemotherapeutics, which could result in markedly reduced toxicity toward …

A variety of cyanines provide versatile and sensitive agents acting as DNA stains and
sensors and have been structurally modified to bind in the DNA minor groove in a sequence …

The binding interactions of six ligands, neutral and monocationic asymmetric monomethine
cyanine dyes comprising benzoselenazolyl moiety with duplex DNA and RNA and G …

A novel dimeric carbocyanine dye is found to recognise G-quadruplex structures selectively
compared to mixed sequence or double-stranded DNA molecules. The dye exhibits a …

The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for
telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited …

We report the synthesis of two new series of triangular aromatic platforms, either with three
aminoalkyl side chains (triazatrinaphthylene series, TrisK: six compounds), or without side …

The discovery of G-quadruplex structures in nucleic acid sequences associated with cancers
has created intense interest in Gquadruplexes as potential drug targets.[1] These …

G-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations,
serve important role in cancer cell growth and control gene expression in telomere. Since …

A series of dimeric cyanine dyes were designed to study their recognition for parallel c-myc
G-quadruplex as well as their spectral features in solution. Dimeric cyanine dyes having …