The aim of the current study was to compare changes in serum biomarkers, including
inflammatory mediators, signaling molecules, growth factors and markers of bone turnover …

Background Modic changes (MC) are associated with low back pain (LBP), but effective
treatments are lacking. The aim of this randomized, placebo-controlled, double-blinded trial …

To assess the safety and efficacy of oral 50 mg Zoledronic acid (ZA) bisphosphate once‐a‐
week for 6‐weeks to placebo among patients with chronic low back pain (cLBP) and Modic …

Background Modic changes (MC) are associated with low back pain (LBP). In this study, we
compared changes in size and type of MC, after a single intravenous infusion of 5 mg …

The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on
low back pain (LBP) and Modic change (MC) over 6 months. Adults aged≥ 40 years with …

Abstract Purpose Lumbar Modic change (MC) can serve as a diagnostic marker as well as
an independent source of chronic low back pain (CLBP). This study aimed to test for the …

Purpose This case-control pilot study examined whether vertebral bone mineral measures
were associated with the presence of chronic low back pain (CLBP) and Modic changes …

We aimed to compare serum biomarkers of inflammation, redox status and cartilage
degradation between chronic low back pain (cLBP) patients with and without Modic 1 …

Background context It is not clear whether Modic changes (MC) is associated with low back
pain (LBP) outcome. Purpose To study associations between baseline degenerative …

Abstract Background The association of Modic changes (MC) with low back pain (LBP) is
unclear. The purpose of our study was to investigate the associations between the extent of …